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Principal Scientist, Immune Oncology Translational Development

Req #: 1800043
Location: Seattle, Offsite US
Job Category: Research and Early Development
Work Location: OFFSITE SEATTLE 99999
Organization: Celgene Corporation
Schedule: 40
Employee Status: Full time
Job Type: Regular
Job Level:
Other Locations:US- WA- Seattle


Celgene is a global biopharmaceutical company leading the way in medical innovation to help patients live longer, better lives. Our purpose as a company is to discover and develop therapies that will change the course of human health.  We value our passion for patients, ​quest for innovation, spirit of independence and love of challenge. With a presence in more than 70 countries, and growing - we look for talented people to grow our business, advance our science and contribute to our unique culture.

The candidate will have responsibility for directing the scientific aspects of preclinical oncology drug development programs and translational medicine correlative studies in Immune Oncology. The successful candidate will be responsible for contributing to translational development strategies for Celgene’s drugs. Expertise in developing and qualifying biomarkers for clinical trials, and strong knowledge in immunology and tumor biology is required. The individual will supervise laboratory based experiments as well as work with contract research organizations and internal and external collaborators. Activities include carrying out mechanism of action studies, biomarker identification, and generation of data that supports patient stratification and the pharmacodynamic evaluation of drugs in the clinical setting.


  • In-depth knowledge of fundamentals of immunology, immune oncology, and tumor biology in solid and hematological malignancies
  • Utilization of translational based approaches to develop new concepts and mechanism of action hypotheses identifying distinguishing characteristic of Celgene compounds alone and in combination with other therapies
  • Knowledge of biomarker discovery and development: assay development/validation, clinical discovery of biomarkers, MoA research, knowledge of platforms
  • Design and execution of primary immune cell based assays
  • Supervise scientific and technical staff
  • Manage internal projects in immune oncology drug development
  • Serve on internal project teams and committees as scientific functional lead
  • Work closely with corporate partners to support preclinical, translational and clinical development of cancer therapeutics.
  • Understand the context, impact and timely communication of data

Specific Duties:

  • Implement in-vitro immunologic assays for evaluating activity and mechanism of action of immune oncology drug candidates using primary cell cultures and patient samples
  • Develop in-vitro and ex-vivo assays to translate preclinical data into clinical biomarkers for advancing drug candidates through clinical trials
  • Critically analyze, interpret, report experimental results; draw appropriate conclusions and design next steps
  • Supervise Associate Scientist(s) and/or Research Associate(s) as needed, and under the direct, but limited supervision of management
  • Participate in Immune Oncology team meetings to present data and provide interpretation
  • Establish and maintain working relationship with contract laboratories and relevant academic collaborators
  • Ensure that the Immune Oncology group maintains current awareness in area of expertise, enhance the scientific credibility of Celgene through contributions to the scientific literature (publications/presentations)
  • Contribute to the writing of investigator brochures, IND applications, clinical protocols, regulatory annual reports, and other regulatory documents when appropriate


  • Ph.D. degree in immunology, tumor biology or cellular biology, or pharmacology with at least 3 years of successful post-doctoral experience, evidenced by a strong publication record, plus a minimum of 10 years of successful experience as a scientist preferably in the biotechnology or pharmaceutical industry setting
  • Excellent communication and interpersonal skills demonstrated in a team environment
  • Expertise in developing biomarkers for clinical trials, and strong knowledge in immunology and tumor biology, knowledge of hematopoietic malignancies desired
  • Relevant skills include proficiency in immunological techniques (flow cytometry, intracellular staining, cytotoxicity assays,  ELISA, ELISpot, etc.), cell biology (transient and stable engineering of cell lines, also using viral transduction, immunocytochemistry, microscopy), and molecular biology (molecular cloning, transient and stable gene silencing, methylation specific PCR) techniques
  • Familiarity with data management tools and software for analyzing translational data sets from various assay formats. Biological interpretation of high content data sets in collaboration with computational biology
  • Effective team building and teamwork skills and ability to interact with and manage research scientists, project teams, outside collaborators and commercial vendors
  • Detail-oriented with the ability to identify and implement creative solutions
  • Ability to prioritize and manage time efficiently


Celgene is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Celgene complies with all applicable national, state and local laws governing nondiscrimination in employment as well as employment eligibility verification requirements of the Immigration and Nationality Act. All applicants must have authorization to work for Celgene in the U.S.
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Celgene is a global biopharmaceutical company committed to improving the lives of patients worldwide. At Celgene, we seek to deliver truly innovative and life-changing treatments for our patients.

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