Principal Scientist, Immuno-oncology, Molecular Medicine

Responsibilities:
 
The candidate will function as Molecular Medicine immuno-biology lead and work collaboratively with systems / computational biology team members for key Celgene assets in hematology and oncology (and autoimmune disorders):
• Generate biological hypotheses (e.g., patient selection, drug combinations, new targets) in various oncology (and non-oncology) disease areas arising from interpretation of Molecular Medicine data
• Implement the Molecular Medicine platform by facilitating research collaborations, contracting, experimental design, experimental execution and data analysis
• Collaborate with Molecular Medicine computational and system biology team members to provide scientific input to their in silico disease modeling efforts 
 
She/he will serve generally as a domain expert in immunology and immuno-oncology for the Molecular Medicine team as well as to others in translational development

She/he will collaborate with colleagues in clinical development on translational sample profiling plans to allow discoveries made in the Molecular Medicine group to be confirmed in larger trial settings
 
As part of the team, the candidate will be responsible for establishing key alliances with academic centers, co-operative groups, and vendors to enable access to relevant tissue types and relevant emerging experimental and computational tools.
 
Results of the scientific projects of the Molecular Medicine group will provide support to Business Development for potential in-licensing opportunities that may include potential therapeutics, emerging technologies, processes or capabilities that will enhance the Molecular Medicine efforts and the Research and Early Development group more broadly

The candidate will be expected to contribute to publications, study reports, invention disclosures, and investigator brochures, as needed, to a publishable standard.

Qualifications
 
PhD in a relevant field (Immunology preferred, Hematology or Oncology accepted), with at least 8 years of relevant post graduate experience (biotechnology or pharmaceutical industry strongly preferred).

Skills/Knowledge Required:

Expert knowledge of oncology disease areas of interest (e.g., multiple myeloma, lymphoma, solid tumors) or autoimmunity (inflammatory bowel disease, lupus, psoriasis, fibrotic diseases)
 
Experience with molecular medicine technologies such as next generation sequencing (DNA, RNA, epigenetics), multi-parameter immune profiling (flow cytometry, CyTOF), and IHC, and experience interpreting data from such analyses

Track record in leading innovative efforts to deploy novel technologies and assays via internal or external collaborations
 
Ability to function at the interface of the Discovery, Development and Commercial teams

Superior leadership, management and organizational skills, and a reputation as an open, available and transparent communicator
 
Proven ability to collaborate and problem-solve productively as a member of an inter-disciplinary team.

Domestic and international travel, as required, 5%