Other Locations:US- CA- San Francisco- Owens Street Celgene
Celgene is a global biopharmaceutical company leading the way in medical innovation to help patients live longer, better lives. Our purpose as a company is to discover and develop therapies that will change the course of human health. We value our passion for patients, quest for innovation, spirit of independence and love of challenge. With a presence in more than 70 countries, and growing - we look for talented people to grow our business, advance our science and contribute to our unique culture.
The Scientist II will contribute to developing strategy and be responsible for experimental design and execution of translational research studies supporting hematological (e.g. myeloid dysplastic syndrome, acute myeloid leukemia, thalassemia, myelofibrosis) disease drug development programs in late clinical development. Ideally, the successful candidate will have research experience in cancer biology with and emphasis in hematological diseases, and pharmacology experience. Flow cytometry experience is highly desired.
Responsibilities will include, but are not limited to, the following:
- Develop strategy, design, execute and interpret experiments to define dose-schedules, patient selection approaches and other biomarker readouts, combination strategies and pathways of drug resistance for oncology programs
- Use in-vivo models, and ex-vivo culture to characterize drug mechanism of action, cellular mechanisms of efficacy, and rational drug combinations
- Lead scientifically in area of expertise
- Interact with project teams, academic collaborators and contract laboratories to design in vitro and in vivo studies to evaluate drug candidates
- Develop and review study proposals, critically review data from contract labs and academic collaborators
- Present work at group meetings, internal forums and scientific conferences
- Author study reports, assay protocols, patent applications, peer-reviewed publications
- Potentially mentor other research staff through instruction, coaching and guidance
- Ph.D. degree in biochemistry, molecular or cellular biology or Scientific discipline with at least 4 years of successful experience as a bench scientist, are required
- Strong publication record
- Comprehensive knowledge of tumor cell biology, molecular oncology, cancer immunology or pharmacology
- Working knowledge of a variety of cellular, biochemical and molecular assays, e.g. proliferation/apoptosis, functional assays, multi-color flow cytometry, primary cell/3-D and co-culture systems, chemotaxis, ELISA, Western blot, RT-PCR, CRSPR/Cas9, RNAi , and next generation sequencing methods.
- Working knowledge of pharmacology models used in cancer biology (including disseminated xenograft, primagraft and syngeneic tumor models)
- The candidate will be a critical experimentalist, results oriented, and enjoy working in a fast-paced environment.
- Ability to develop a research plan, conduct experimental work with accurate and detailed record keeping
- Excellent organizational skills with the ability to efficiently manage and prioritize multiple projects, internal and external collaborations
- Ability to interpret and summarize scientific data in an accurate, critical and concise manner
- Excellent oral and written communication skills
- Strong independent problem-solving skills
- Flexible and adaptable to changing priorities
- Must be willing to work with a highly motivated team, pursuing goals aggressively
- Excellent teamwork, organizational and communication skills are essential.
Prerequisites: PhD in a Scientific discipline with at least 4 years of bench work experience.
Celgene is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Celgene complies with all applicable national, state and local laws governing nondiscrimination in employment as well as employment eligibility verification requirements of the Immigration and Nationality Act. All applicants must have authorization to work for Celgene in the U.S.